Overmethylation

Histapenia (overmethylation) is a shortage of histamine in the body. Histamine is a major brain neurotransmitter, but is known popularly for its role in allergic symptoms. Patients with low blood histamine tend to have depressed metabolism, a pear shaped body and some may have certain psychological conditions such as anxiety and classic schizophrenic symptoms (paranoia, grandiosity, hallucinations).

OVERMETHYLATION (HISTAPENIA):
Clinical Characteristics
Poor achiever - Poor motivation - Artistic/musical ability - High anxiety/panic - Low libido - Overweight - Easily frustrated - Sleep disorder - Paranoia - Depression - Self mutilation - Self isolation - Nervousness - Tinnitis  - Food/chemical sensitivities - High pain threshold - Past Hx ADHD - Hyperactive psychosis - Religiosity - Grandiosity - Nil family history - Hirsutism - Eczema/dry skin

BIOCHEMISTRY OF OVERMETHYLATION
    Low histamine
    Low Zinc
    Low basophil count
    Copper overload

OVERMETHYLATION: Medication Reactions
    Adverse reaction anti-histamines
    Good response benzodiazepines
    Adverse reaction SSRIs
    Improvement on Lithium
    Adverse reaction oestrogen therapy
    Adverse reaction Methionine/ SAMe

References.

https://custommedicine.com.au/health-articles/histapenia-over-methylation/

http://secondopinionphysician.com/tag/overmethylation/

https://naturalhealthmedicine.com.au/overmethylation/

http://www.corepsych.com/2014/09/overmethylation-depression-walsh/

https://liveto110.com/93-overmethylation-undermethylation-dr-albert-mensah/

http://www.walshinstitute.org/biochemical-individuality--nutrition.html

http://www.gethelpfordepression.info/overmethylation.aspx

http://www.americanherbalistsguild.com/sites/default/files/Proceedings/light_phyllis-_the_methylation_cycle_and_mental_health.pdf.

https://www.researchgate.net/publication/261000483_Slow_Overmethylation_of_Housekeeping_Genes_in_the_Body_Mucosa_Is_Associated_with_the_Risk_for_Gastric_Cancer